Triazine condensing agents such as DMT-MM are one of attractive condensing agents. The advantage of this reagent is that low alcohol or water can be used as a solvent for esterification or amidation reaction. It is a very useful for the reaction of water or lower alcohol soluble material. Since by-product that is generated from DMT-MM after reaction is water-soluble, they can be easily removed by washing at extraction step.
The amidation reaction in alcohol solvents
＊b：N-Acylurea was isolated in 21%
- Kunishima, M., Kawachi, C., Morita, J., Terao, K., Iwasaki, F. and Tani, S. : Tetrahedron, 55, 13159 (1999).
- M. Kunishima, C. Kawachi, K. Hioki, K. Terao, S. Tani : Tetrahedron, 57, 1551（2001）.
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