NG-Nitro-L-arginine Methyl Ester Hydrochloride

for Biochemistry

Specification Assay :: 98.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at 2-10 degrees C. (RT)

CAS RN^® :: 51298-62-5
Molecular Formula :: C7H15N5O4・HCl
Molecular Weight :: 269.69

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Product Number	Package Size	Price	Availability	Certificate of Analysis	Purchase
Distributor 141-06104 Barcode No 4987481386945	1G	List Price 111.00 USD	In stock in Japan	Certificate of Analysis	Distributor
Distributor 143-06103 Barcode No 4987481303935	10g		Discontinued	Certificate of Analysis	Distributor
Distributor 147-06101 Barcode No 4987481303911	100mg	List Price 63.00 USD	In stock in Japan	Certificate of Analysis	Distributor

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Overview / Applications

Outline	NO synthase inhibitors inhibit endothelial cells from releasing NO by inhibiting NOS, or through competitive inhibition of the production of NO. Two types of NOS, i.e. the non-derivation type and the derivation type are now known. The former is generally present in endothelial cells and nerve cells, and the latter is induced by cytokines in macrophages and neutrophils. The non-derivation type is dependent on calcium-calmodulin (Ca2+/CM) and NADPH, and the NO produced acts as a signaling substance for the activation of soluble guanylate cyclase of vascular endothelial cells. On the other hand, the derivation type of NO synthase is dependent on NADPH but not on Ca2+/CM, and it is known to require tetrahydrobiopterin in macrophages. The NO produced is believed to function as a cytotoxic mechanism. L-NMMA, L-NNA and L-NAME have strong inhibitory effects on the non-derivation type, but weaker inhibitory effects on the derivation type, and L-NIO, which is inferior in action to L-NMMA, has been reported to exhibit a stronger inhibitory effect on the non-derivation type. It is more highly soluble than NG-Nitro-L-arginine and acts competitively with L-arginine by inhibiting the NO synthase.

Outline

NO synthase inhibitors inhibit endothelial cells from releasing NO by inhibiting NOS, or through competitive inhibition of the production of NO.
Two types of NOS, i.e. the non-derivation type and the derivation type are now known. The former is generally present in endothelial cells and nerve cells, and the latter is induced by cytokines in macrophages and neutrophils. The non-derivation type is dependent on calcium-calmodulin (Ca2+/CM) and NADPH, and the NO produced acts as a signaling substance for the activation of soluble guanylate cyclase of vascular endothelial cells. On the other hand, the derivation type of NO synthase is dependent on NADPH but not on Ca2+/CM, and it is known to require tetrahydrobiopterin in macrophages. The NO produced is believed to function as a cytotoxic mechanism. L-NMMA, L-NNA and L-NAME have strong inhibitory effects on the non-derivation type, but weaker inhibitory effects on the derivation type, and L-NIO, which is inferior in action to L-NMMA, has been reported to exhibit a stronger inhibitory effect on the non-derivation type.
It is more highly soluble than NG-Nitro-L-arginine and acts competitively with L-arginine by inhibiting the NO synthase.

Property

Appearance	White, crystals - powder
Specific Rotation	+14.5 - 16.5 degrees (D/20degrees C) (c=3, CH3OH)

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For research use or further manufacturing use only. Not for use in diagnostic procedures.

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