Lithium Dodecyl Sulfate(LDS)

for Biochemistry

Specification Assay :: 95.0+% (Capillary GC)
98.0+% (Titration)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at 2-10 degrees C. (RT)

CAS RN^® :: 2044-56-6
Molecular Formula :: CH3(CH2)11OSO3Li
Molecular Weight :: 272.33

GHS :

Structural Formula
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SDS

Comparison	Product Number	Package Size	Price	Inventory
	Distributor 121-02741 Barcode No 4987481285835	10g	List Price 103.00 USD	In stock in Japan	Certificate of Analysis

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SDS

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Overview / Applications

Outline	Solubility: Water (0.7g/10mL)Dodecyl sulfate (lauryl sulfate) used either as the sodium salt (SDS) or the more soluble lithium salt (LDS) is a powerful detergent that has found wide application in the analytical biochemistry of nucleic acids because of its ability to release nucleic acids from their associations with protein or lipoprotein structures in which they normally occur inside the cell. Recently, the amide derivative sodium dodecyl sarcosinate has been introduced because of its solubility in high concentrations of cesium chloride. The precise mechanism of action of these detergents is not known, but it is likely that the hydrocarbon chain of SDS competes for hydrophobic bonds. This tendency in combination with the strongly hydrophilic sulfate group presumably causes the formation of water-soluble complexes or micelles. Two additional properties make dodecyl sulfate particularly suitable for use in nucleic acid isolation: the anionic detergent appears to be an inhibitor of nucleases, and its negative charge prevent it from interaction with nucleic acids.Ref.: The Use of Sodium and Lithium Dodecyl Sulfate in Nucleic Acid Isolation, Hans Noll and Erhard Stutz, Methods in Enzymol, Vol. 12, 129-155.

Outline

Solubility: Water (0.7g/10mL)Dodecyl sulfate (lauryl sulfate) used either as the sodium salt (SDS) or the more soluble lithium salt (LDS) is a powerful detergent that has found wide application in the analytical biochemistry of nucleic acids because of its ability to release nucleic acids from their associations with protein or lipoprotein structures in which they normally occur inside the cell. Recently, the amide derivative sodium dodecyl sarcosinate has been introduced because of its solubility in high concentrations of cesium chloride. The precise mechanism of action of these detergents is not known, but it is likely that the hydrocarbon chain of SDS competes for hydrophobic bonds. This tendency in combination with the strongly hydrophilic sulfate group presumably causes the formation of water-soluble complexes or micelles. Two additional properties make dodecyl sulfate particularly suitable for use in nucleic acid isolation: the anionic detergent appears to be an inhibitor of nucleases, and its negative charge prevent it from interaction with nucleic acids.Ref.: The Use of Sodium and Lithium Dodecyl Sulfate in Nucleic Acid Isolation, Hans Noll and Erhard Stutz, Methods in Enzymol, Vol. 12, 129-155.

Property

Appearance	White, crystals - powder or mass
pH	pH(0.25mol/l, 25 degrees C) :5.0 - 10.5

Manufacturer Information

Alias

Lithium dodecylsulfate, Dodecylsulfate, lithium salt

Same CAS list

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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