17-AAG
- for Cellbiology
- Specification Assay :
- 97.0+% (HPLC)
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- CAS RN® :
- 75747-14-7
- Molecular Formula :
- C31H43N3O8
- Molecular Weight :
- 585.69
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1mg
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Out of Stock |
※Check availability in the US with the distributor.
Document
Overview / Applications
| Outline | A synthetic derivative of geldanamycin, which is one of the ansamycin antibiotics.HSP90 (Heat Shock Protein 90) is related to molecular chaperone and plays a role in maintaining the activity of signal transduction molecules in the signal transduction pathway. 17-AAG inhibits the function of HSP90 by binding to the ATP binding site of HSP90 (EC50=7.2 micro M).HSP90 inhibitors dephosphorylate Akt resulting in inactivation of Akt and apoptosis. |
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Property
| Appearance | Red - dark purple, crystalline powder - powder |
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Manufacturer Information
Alias
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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