Prednisolone

for Biochemistry

Specification Assay :: 97.0 - 103.0% (molecular absorptiometric analysis)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at RT.

CAS RN^® :: 50-24-8
Molecular Formula :: C21H28O5
Molecular Weight :: 360.44

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 165-11491 Barcode No 4987481314337	1G	Inquire	In stock in Japan	Certificate of Analysis
	Distributor 161-11493 Barcode No 4987481314344	5G	Inquire	In stock in Japan	Certificate of Analysis

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Application

Overview / Applications

Outline	The uppermost surface of the adrenal cortex is covered with connective tissues followed by the zona glomerulosa, zona fasciculata and zona reticularis from outside to inside, and the further inner part is medulla.Mineral corticoid is secreted from the zona glomerulosa, glucocorticoid from the zona fasciculata, and sex hormone (follicular hormone, corpus luteum hormone, androgenic hormone) from the zona reticularis.Representative naturally-occurring glucocorticoids include corticosterone and cortisone, and more potent synthetic glucocorticoids with minor adverse effects include prednisolone, triamcinolone and betamethasone.1. Increased blood glucose: Increases blood glucose by inhibiting incorporation/utilization of glucose in the peripheral part.2. Fat metabolism: Has no direct action to decompose fats but enhances lipolysis by other hormones and cyclic AMP.3. Inhibition of vascular hyperpermeability: Constricts peripheral vessels to inhibit vascular hyperpermeability by increasing the sensitivity of smooth muscles to catecholamine.4. Proinflammatory/antiallergic: Inhibits prostaglandin production and reduces inflammation induction and fever. It also inhibits immune response and allergic reaction.Synthetic glucocorticoid. Compared to natural glucocorticoid, it has stronger antiinflammatory action and weaker adverse effects. Its antiinflammatory action is 5 times as strong as cortisone. A non-naturally occurring synthetic steroid hormone, with adrenocortical hormone action.

Outline

The uppermost surface of the adrenal cortex is covered with connective tissues followed by the zona glomerulosa, zona fasciculata and zona reticularis from outside to inside, and the further inner part is medulla.Mineral corticoid is secreted from the zona glomerulosa, glucocorticoid from the zona fasciculata, and sex hormone (follicular hormone, corpus luteum hormone, androgenic hormone) from the zona reticularis.Representative naturally-occurring glucocorticoids include corticosterone and cortisone, and more potent synthetic glucocorticoids with minor adverse effects include prednisolone, triamcinolone and betamethasone.1. Increased blood glucose: Increases blood glucose by inhibiting incorporation/utilization of glucose in the peripheral part.2. Fat metabolism: Has no direct action to decompose fats but enhances lipolysis by other hormones and cyclic AMP.3. Inhibition of vascular hyperpermeability: Constricts peripheral vessels to inhibit vascular hyperpermeability by increasing the sensitivity of smooth muscles to catecholamine.4. Proinflammatory/antiallergic: Inhibits prostaglandin production and reduces inflammation induction and fever. It also inhibits immune response and allergic reaction.Synthetic glucocorticoid. Compared to natural glucocorticoid, it has stronger antiinflammatory action and weaker adverse effects. Its antiinflammatory action is 5 times as strong as cortisone.
A non-naturally occurring synthetic steroid hormone, with adrenocortical hormone action.

Property

Appearance	White - nearly white, crystalline powder - powder
Melting Point	about 235 degrees C (dec.)
Specific Rotation	+97 - +103 degrees (20 degrees C/D)(c=0.5,1,4-dioxane)

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Related Information

Product List

Product Name
Beclomethasone Dipropionate	for Pharmacology Research
Betamethasone	for Biochemistry
Betamethasone Dipropionate	for Biochemistry
Betamethasone Valerate	for Biochemistry
Clobetasol Propionate Discontinued	for Biochemistry
Dexamethasone	for Biochemistry
Dexamethasone Sodium Phosphate	for Pharmacology Research
Hydrocortisone	Wako Special Grade
Hydrocortisone Acetate Discontinued	for Pharmacology Research
Triamcinolone Acetonide	for Biochemistry
Adrenocorticotropic Hormone (1-24)(Human)	for Cellbiology
Chlormadinone Acetate Discontinued	for Biochemistry
Danazol Discontinued	for Biochemistry
β-Estradiol	for Biochemistry
Medroxyprogesterone Acetate	for Biochemistry
Testosterone Enanthate	for Cellbiology

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