Medroxyprogesterone Acetate

for Biochemistry

Specification Assay :: 98.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at RT.

CAS RN^® :: 71-58-9
Molecular Formula :: C24H34O4
Molecular Weight :: 386.52

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 138-09991 Barcode No 4987481296244	1G	Inquire	In stock in Japan	Certificate of Analysis
	Distributor 134-09993 Barcode No 4987481296251	5G	Inquire	Inquire	Certificate of Analysis

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Overview / Applications

Outline	Primary follicles mature into Graafian follicles by the action of FSH, and begin to secrete estradiol. This estradiol causes the endometrium to proliferate, while FSH secretion is inhibited (feedback control), resulting in enhanced LH secretion. Graafian follicles are stimulated by LH, and proceed to ovulation and luteinization. LH stimulates the corpus luteum to secrete progesterone, enhances the development of uterine gland tubes and shifts the endometrium to the secretory phase (fully functioning state), while progesterone decreases oxytocin susceptibility of the uterus.Physiological effectFollicular hormone (estradiol); 1. Proliferation of endometrium2. Expression of secondary sexual characteristics3. Increased oxytocin sensitivity of the uterus4. Inhibition of FSH secretion (feedback control)Corpus luteum hormone (progesterone); 1. Changes the endometrium into a secretory phase endometrium (implantation of fertilized egg)2. Hyperthermic action (stimulation of heat center)3. Inhibition of LH secretion4. Reduction of oxytocin susceptibility of the uterus (prevention of miscarriage)Luteinizing hormone agonist having an antitumor activity. Neovascularization inhibitor. Corpus luteum hormone agonist with antitumor activity. Luteinizing hormone agonist with antitumor activity. It has attracted attention as a neovascularization inhibitor.

Outline

Primary follicles mature into Graafian follicles by the action of FSH, and begin to secrete estradiol. This estradiol causes the endometrium to proliferate, while FSH secretion is inhibited (feedback control), resulting in enhanced LH secretion. Graafian follicles are stimulated by LH, and proceed to ovulation and luteinization. LH stimulates the corpus luteum to secrete progesterone, enhances the development of uterine gland tubes and shifts the endometrium to the secretory phase (fully functioning state), while progesterone decreases oxytocin susceptibility of the uterus.Physiological effectFollicular hormone (estradiol); 1. Proliferation of endometrium2. Expression of secondary sexual characteristics3. Increased oxytocin sensitivity of the uterus4. Inhibition of FSH secretion (feedback control)Corpus luteum hormone (progesterone); 1. Changes the endometrium into a secretory phase endometrium (implantation of fertilized egg)2. Hyperthermic action (stimulation of heat center)3. Inhibition of LH secretion4. Reduction of oxytocin susceptibility of the uterus (prevention of miscarriage)Luteinizing hormone agonist having an antitumor activity. Neovascularization inhibitor. Corpus luteum hormone agonist with antitumor activity.
Luteinizing hormone agonist with antitumor activity. It has attracted attention as a neovascularization inhibitor.

Property

Appearance	White - slightly brown, crystals - powder
Melting Point	about 208 degrees C
Specific Rotation	+45 - +52 degrees(D/20 degrees C)(c=1, 1,4-dioxane)

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