Glibenclamide

for Biochemistry

Specification Assay :: 98.0+% (Titration)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at RT.

CAS RN^® :: 10238-21-8
Molecular Formula :: C23H28ClN3O5S
Molecular Weight :: 494.00

Citations (1)

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Packing

Comparison	Product Number	Package Size	Price	Inventory
	Distributor 078-03881 Barcode No 4987481272798	5G	Inquire	In stock in Japan	Certificate of Analysis
	Distributor 076-03882 Barcode No 4987481272804	25G	Inquire	In stock in Japan	Certificate of Analysis

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Application
Overview / Applications
Property
Manufacturer Information
Alias
Same CAS list
Related Information

Document

Product Specification Sheet

Spectral Data

Certificate of Analysis

Calibration Certificate

Application

Overview / Applications

Outline	>Glucagon, with a hyperglycemic action, and insulin, with a hypoglycemic action, are secreted from alpha and beta cells, respectively, of the islands of Langerhans to control blood glucose.Sulfonylurea hypoglycemic substance. It blocks ATP-dependent K+ channel of the pancreas to increase intracellular Ca2+, thus increasing insulin secretion. It pharmacologically antagonizes the action of K+ channel-opening agents in the heart and blood vessels. Product List for Research of Diabetes -SU compounds- · Chlorpropamide (Wako Cat. #032-21482; 034-21481) · Glibenclamide (Wako Cat. #078-03881; 076-03882) · Gliclazide (Wako Cat. #071-04731; 079-04732) · Glimepiride (Wako Cat. #071-05691; 077-05693) · Tolazamide (Wako Cat. #202-15211; 200-15212) · Tolbutamide (Wako Cat. #209-09172) -Nateglinide- · Nateglinide (Wako Cat. #146-08751; 142-08753) Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, stimulates insulin secretion by closing the ATP-sensitive K⁺ (K_ATP) channels in pancreatic beta; cells. -Biguanide class- · Metformin Hydrochloride (Wako Cat. #138-15481; 130-15481) -Thiazolidinedione class PPAR gamma; agonist- · Rosiglitazone (Wako Cat. #186-02471; 182-02473) · Troglitazone (Wako Cat. #207-17601; 203-17603) · Ciglitazone (Wako Cat. #030-20981)

Outline

>Glucagon, with a hyperglycemic action, and insulin, with a hypoglycemic action, are secreted from alpha and beta cells, respectively, of the islands of Langerhans to control blood glucose.Sulfonylurea hypoglycemic substance. It blocks ATP-dependent K+ channel of the pancreas to increase intracellular Ca2+, thus increasing insulin secretion. It pharmacologically antagonizes the action of K+ channel-opening agents in the heart and blood vessels.

Product List for Research of Diabetes
-SU compounds-
· Chlorpropamide (Wako Cat. #032-21482; 034-21481)
· Glibenclamide (Wako Cat. #078-03881; 076-03882)
· Gliclazide (Wako Cat. #071-04731; 079-04732)
· Glimepiride (Wako Cat. #071-05691; 077-05693)
· Tolazamide (Wako Cat. #202-15211; 200-15212)
· Tolbutamide (Wako Cat. #209-09172)

-Nateglinide-
· Nateglinide (Wako Cat. #146-08751; 142-08753)
Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea
or benzamido moiety, stimulates insulin secretion by closing the ATP-sensitive
K⁺ (K_ATP) channels in pancreatic beta; cells.

-Biguanide class-
· Metformin Hydrochloride (Wako Cat. #138-15481; 130-15481)

-Thiazolidinedione class PPAR gamma; agonist-
· Rosiglitazone (Wako Cat. #186-02471; 182-02473)
· Troglitazone (Wako Cat. #207-17601; 203-17603)
· Ciglitazone (Wako Cat. #030-20981)

Property

Appearance	White - slightly yellow, crystals - powder
Melting Point	about 276 degrees C

Manufacturer Information

Alias

Same CAS list

Related Information

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