LC Solvents for JP, USP, Ph. Eur.
The solvents for the Pharmacopoeia General Test (for LC) comply with the reagent grades of the Japanese Pharmacopoeia, the United States Pharmacopeia (USP), and the European Pharmacopoeia (EP, Ph. Eur.). It supports global pharmaceutical tests. USP and Ph. Eur. have different grades for different applications within the same solvent type, and the absorbance measurement wavelength range and content specification values are defined according to the grade. Our solvent for the Pharmacopoeia General Test (for LC) grade is assured up to the highest grade of both USP and Ph. Eur. And we assure our own test items and stricter specifications in addition to the specifications of each pharmacopeia.
Features
- Compatible with the solvent standards of the Japanese Pharmacopoeia, USP (ACS), and Ph. Eur.
- In addition to General Use, assures up to Specific Use (UV Spectrophotometry, LC Suitability) grades. (USP)
- Assures R1 for acetonitrile and R1 and R2 for methanol. (Ph. Eur.)
- We have added our own test items and specification values, and some of them are assured to be stricter than the specifications of each pharmacopeia.
Comparison of the Specifications of Each Pharmacopeia and Our Product Assure Items
Comparison of the specifications of each pharmacopeia and our assured items for the Japanese Pharmacopoeia General Tests (for LC) (Acetonitrile)*
| Item | JP | USP | Ph. Eur. | Assured items for the Japanese Pharmacopoeia General Tests |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| for Liquid chromatography |
ACS | Spectro photometric |
Spectro photometry |
for Chromatography |
R1 | |||||
| General use |
Specific Use | |||||||||
| UV spectrophotometry |
LC suitability |
|||||||||
| Description | Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid |
Colorless clear liquid (JP, USP, EP) |
|
| Assay | - | min. 99.5% | min. 99.5% | min. 99.5% | min. 99.5% | - | min. 99.8% | min. 99.9% | min. 99.5% (USP) min. 99.9% (EP) |
|
| Distillation range (80～82℃) |
Not less than 95% | Not less than 95% | Not less than 95% | Not less than 95% (EP) | ||||||
| Density (20℃) | - | - | - | - | - | - | - | - | 0.780～0.783 g/mL | |
| Specific gravity ( d2020 ) | - | - | - | - | - | about 0.78 | about 0.78 | about 0.78 | about 0.78 (EP) | |
| Refractive index (n20D) | - | - | - | - | - | about 1.344 | about 1.344 | about 1.344 | about 1.344 (EP) | |
| Absor- bance |
190 nm | - | - | max. 1.00 | max. 1.00 | - | - | - | - | max. 1.00 (USP) |
| 200 nm | max. 0.07 | - | - | - | - | - | - | max. 0.10 | max. 0.07 (JP) max. 0.10 (EP) |
|
| 210 nm | max. 0.046 | - | - | - | - | - | - | - | max. 0.03 | |
| 220 nm | max. 0.027 | - | max. 0.05 | max. 0.05 | - | - | - | - | max. 0.027 (JP) max. 0.05 (USP) |
|
| 230 nm | max. 0.014 | - | - | - | - | - | - | - | max. 0.014 (JP) | |
| 240 nm | max. 0.009 | - | - | - | - | - | max. 0.01 | - | max. 0.009 (JP) | |
| 250 nm | - | - | - | - | max. 0.01 | - | - | max. 0.01 (EP) | ||
| 254 nm | - | - | max. 0.01 | max. 0.01 | - | - | max. 0.01 (USP, EP) | |||
| 255 nm | - | - | - | - | max. 0.01 | - | max. 0.01 (USP, EP) | |||
| 280 nm | - | - | - | - | - | max. 0.01 (USP, EP) | ||||
| 420 nm | - | - | - | - | - | - | max. 0.01 (EP) | |||
| Fluorescence test | - | - | - | - | - | - | - | - | to pass test | |
| Water (H2O) | - | max. 0.3% | max. 0.3% | max. 0.3% | max. 0.3% | - | - | - | max. 0.3% (USP) | |
| Residue after evaporation | - | max. 0.005% | max. 0.005% | max. 0.005% | max. 0.005% | - | - | - | max. 0.005% (USP) | |
| Titrable acid |
equivalent | - | max. 8 μeq/g | max. 8 μeq/g | max. 8 μeq/g | max. 8 μeq/g | - | - | - | max. 8 μeq/g (USP) |
| CH3COOH | - | - | - | - | - | - | - | - | max. 0.001% | |
| Titrable base |
equivalent | - | max. 0.6 μeq/g | max. 0.6 μeq/g | max. 0.6 μeq/g | max. 0.6 μeq/g | - | - | - | max. 0.6 μeq/g (USP) |
| NH4 | - | - | - | - | - | - | - | - | max. 0.3 ppm | |
| Color (APHA) | - | max. 10 | max. 10 | max. 10 | max. 10 | - | - | - | max. 10 (USP) | |
| Gradient elution | - | - | - | to pass test | - | - | - | - | to pass test (USP) | |
| pH | - | - | - | - | - | Neutral to litmus paper |
Neutral to litmus paper |
Neutral to litmus paper |
Neutral to litmus paper (EP) |
|
| Peroxide (as H2O2) | - | - | - | - | - | - | - | - | max. 5 ppm | |
| Substances reducing permanganate |
- | - | - | - | - | - | - | - | to pass test | |
Corresponding Range of Our Solvent (for the Japanese Pharmacopoeia General Test (for LC) grade) in Each Pharmacopeia Solvent Type*1
| Item | JP | USP | Ph. Eur. | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| for Liquid chromatography |
ACS | Spectro photometric |
Spectro photometry |
for Chromatography |
R*2 | R1 | R2 | |||
| General Use |
Specific Use | |||||||||
| UV Spectrophotometry |
LC Suitability |
|||||||||
| Acetonitrile | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| Methanol | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Hexane | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
| Tetrahydrofuran, Stabilizer Free*3 |
✓ | ✓ | - | - | - | |||||
*2 R: Reagant
*3 Ph. Eur. is not assured.
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For research use or further manufacturing use only. Not for use in diagnostic procedures.
Product content may differ from the actual image due to minor specification changes etc.
If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.