Puromycin-Sensitive Aminopeptidase (PSA) Fluorescent Probe
C31H32O4N4S=556.68
DAMPAQ-22 is a fluorescent probe developed based on PAQ-22. Same as PAQ-22, it specifically inhibits PSA activity. It can be used to visualize PSA in vivo.
Product Information
- Synonym:：N-[4-(1,4-Dihydro-1-methyl-2,4-dioxo-3(2H)-quinazolinyl)-3,5-diethylphenyl]-5-(dimethylamino)-1-naphthalenesulfonamide
- Appearance: White to slightly brown, crystalline powder to powder
- Solubility: DMSO ＜10 mmol/L
- IC50 for PSA: 4.6 μmol/L
IC50 for APN: >100 μmol/L - λex：320 nm / λem：510 nm
* Excitation wavelength and fluorescence wavelength are not optimized. Please change λex andλem according to your experimental condition and purpose.
Visualization of PSA in MOLT-4 cells
MOLT-4 cells were treated with 10 μmol / L DAMPAQ-22 for 10 minutes.
Data provided by Dr. Yuichi Hashimoto, Institute of Molecular Cell Biology, University of Tokyo
References
- Kakuta, H., Tanatani, A., Nagasawa, K. and Hashimoto, Y. : Chem. Pharm. Bull., 51, 1273(2003).
- Kakuta, H., Koiso, Y., Nagasawa, K. and Hashimoto, Y. : Bioorg. Med. Chem. Lett., 13, 83(2003).
- Bukowska, A., Tadje, J., Arndt, M., Wolke, C., Kahne, T., Bartsch, J., Faust, J., Neubert, K., Hashimoto, Y. and Lendeckel, U. : Biol. Chem., 384, 657(2003).
- Sanchez-Moran, E., Jones, G.H., Franklin F.C. and Santos, J.L. : Plant Cell, 16, 2895(2004).
- Thielitz, A., Bukowska, A., Wolke, C., Vetter, R., Lendeckel, U., Wrenger, S., Hashimoto, Y., Ansorge, S., Gollnick, H. and Reinhold, D. : Biochem. Biophys. Res. Commun., 321, 795(2004).
- 和光純薬時報, 77(1), 2(2009).
Product List
- Open All
- Close All
For research use or further manufacturing use only. Not for use in diagnostic procedures.
Product content may differ from the actual image due to minor specification changes etc.
If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.