Resveratrol

for Biochemistry

Specification Assay :: 98.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

CAS RN^® :: 501-36-0
Molecular Formula :: C14H12O3
Molecular Weight :: 228.24

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 185-01721 Barcode No 4987481407107	100mg	List Price JPY 25,400	In stock in Japan	Certificate of Analysis
	Distributor 181-01723 Barcode No 4987481407114	500mg		Discontinued	Certificate of Analysis

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100mg
500mg

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Overview / Applications

Outline	Resveratrol is a selective inhibitor of cyclooxygenase-1 (COX-1) (ED50=15 μM). It inhibits hydroperoxygenase activities of COX-1 (ED50=3.7 μM). This product is for research use only. Do not administer it to human. Cell Biological Research For Research on Cell Cycle and TranscriptionHistone Deacetylase (HDAC) Activators Histone deacetylase (HDAC) plays a central role in chromatin structure formation associated with the nuclear distribution of DNA. There are presently 17 known types of this enzyme in mammals, which are classified into 3 classes (see below). Also, HDAC Class III has been reported to be associated with regulation of aging and life span. Mammalian HDAC Class I: Localized in the nucleus. Similar to RPD3 enzyme. [Types: HDAC1-3, 8] Mammalian HDAC Class II: Localized in the nucleus and cytoplasm and shuttles between the two. Similar to HDAC1 enzyme. [Types: HDAC4-7, 9, 10] Mammalian HDAC Class III: NAD-dependent enzyme. Localized in the nucleus and cytoplasm. Also called Sirtuin and is similar to SIR2 enzyme. [Types: Sirt 1-7] Resveratrol, which is a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD(+), and increasescell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan by 70%¹⁾. [Product List] Butein (Wako Cat.#027-14461 (10 mg)) Inhibitor of tyrosine kinase and Activator of SIRT1 (Class III HDAC). Piceatannol (Wako Cat.#169-21661 (10 mg)) Selective inhibitor of protein tyrosine kinase Syk and Activator of SIRT1 (Class III HDAC). Resveratrol (Wako Cat.#185-01721 (100 mg); #181-01723 (500 mg)) Inhibitor of COX-1 and Activator of SIRT1 (Class III). [Reference]1) Howitz, K. T., et al.: Nature, 425, 191 (2003).
Precautions for Use	Packed on inactive gas

Outline

Resveratrol is a selective inhibitor of cyclooxygenase-1 (COX-1) (ED50=15 μM). It inhibits hydroperoxygenase activities of COX-1 (ED50=3.7 μM).
This product is for research use only. Do not administer it to human.

Cell Biological Research

For Research on Cell Cycle and TranscriptionHistone Deacetylase (HDAC) Activators
Histone deacetylase (HDAC) plays a central role in chromatin structure formation associated with the nuclear distribution of DNA. There are presently 17 known types of this enzyme in mammals, which are classified into 3 classes (see below). Also, HDAC Class III has been reported to be associated with regulation of aging and life span.

Mammalian HDAC Class I: Localized in the nucleus. Similar to RPD3 enzyme. [Types: HDAC1-3, 8]

Mammalian HDAC Class II: Localized in the nucleus and cytoplasm and shuttles between the two. Similar to HDAC1 enzyme. [Types: HDAC4-7, 9, 10]

Mammalian HDAC Class III: NAD-dependent enzyme. Localized in the nucleus and cytoplasm. Also called Sirtuin and is similar to SIR2 enzyme. [Types: Sirt 1-7]

Resveratrol, which is a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD(+), and increasescell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan by 70%¹⁾.

[Product List]
Butein (Wako Cat.#027-14461 (10 mg)) Inhibitor of tyrosine kinase and Activator of SIRT1 (Class III HDAC).
Piceatannol (Wako Cat.#169-21661 (10 mg)) Selective inhibitor of protein tyrosine kinase Syk and Activator of SIRT1 (Class III HDAC).
Resveratrol (Wako Cat.#185-01721 (100 mg); #181-01723 (500 mg)) Inhibitor of COX-1 and Activator of SIRT1 (Class III).

[Reference]1) Howitz, K. T., et al.: Nature, 425, 191 (2003).

Precautions for Use

Packed on inactive gas

Property

Appearance	White - pale brown, crystalline powder - powder or mass
Melting Point	263 - 270 degrees C.

Manufacturer Information

Alias

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