N,N-Dicyclohexyl-1,3,2-dioxaphospholan-2-amine

for Nucleic Acid Synthesis

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

CAS RN^® :: 28623-32-7
Molecular Formula :: C14H26NO2P
Molecular Weight :: 271.34

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 044-35191 Barcode No 4548995108463	1G	List Price JPY 30,000	In stock in Japan	Certificate of Analysis

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Overview / Applications

Outline	EDCP (Ethano N,N-dicyclohexylphosphoramidite) is a capping reagent for oligonucleotide synthesis, characterized by low steric hindrance and high reactivity. This reagent was developed by the research group of Professor Yoshiyuki Hari at Tokushima Bunri University. Acetyl protection using acetic anhydride is widely used as a capping reagent. However, acetyl-based capping suffers from the problem of impurity generation due to side reactions, such as substitution reactions with the protecting groups on the nucleobase portion. Furthermore, the acetyl capping reaction has low reactivity with secondary alcohols, such as the hydroxyl group of universal linkers or the 3'-hydroxyl group of nucleic acids. Consequently, unreacted species (uncapped nucleotides) remain, contributing to impurities. This product is a novel capping reagent that avoids impurity issues caused by such side reactions and low reactivity.

Outline

EDCP (Ethano N,N-dicyclohexylphosphoramidite) is a capping reagent for oligonucleotide synthesis, characterized by low steric hindrance and high reactivity. This reagent was developed by the research group of Professor Yoshiyuki Hari at Tokushima Bunri University.
Acetyl protection using acetic anhydride is widely used as a capping reagent. However, acetyl-based capping suffers from the problem of impurity generation due to side reactions, such as substitution reactions with the protecting groups on the nucleobase portion. Furthermore, the acetyl capping reaction has low reactivity with secondary alcohols, such as the hydroxyl group of universal linkers or the 3'-hydroxyl group of nucleic acids. Consequently, unreacted species (uncapped nucleotides) remain, contributing to impurities.
This product is a novel capping reagent that avoids impurity issues caused by such side reactions and low reactivity.

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EDCP
Ethano N,N-dicyclohexylphosphoramidite

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Product List

Product Name
Cap A Solution-1 (10vol% Acetic anhydride/Tetrahydrofuran Solution)	for Nucleic Acid Synthesis
Cap B Solution-1[Tetrahydrofuran/1-Methylimidazole/Pyridine (8:1:1) Solution]	for Nucleic Acid Synthesis
Cap A Solution-2[Tetrahydrofuran/Acetic Anhydride/Pyridine (8:1:1) Solution]	for Nucleic Acid Synthesis
Cap B Solution-2 (10vol% 1-Methylimidazole/Tetrahydrofuran Solution)	for Nucleic Acid Synthesis
Cap B2 Solution [Pyridine-Acetonitrile (4:6)]	for Nucleic Acid Synthesis
Cap B Solution [Acetic Anhydride-2,6-Lutidine-Acetonitrile (2:3:5)]	for Nucleic Acid Synthesis
Cap B2 Solution [2,6-Lutidine-Acetonitrile (6:4)]	for Nucleic Acid Synthesis
Cap B1 Solution [Acetic Anhydride-Acetonitrile (4:6)]	for Nucleic Acid Synthesis

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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