FM Fix
Tissue fixation is a critical process for protecting biological samples from degradation due to autolysis or decay, ensuring the stable preservation of proteins and other tissue components. Although formalin fixation is widely used in research and pathology, particularly in preparing microscopic specimens, it can alter the tertiary structure and antigenicity of certain proteins, leading to diminished staining quality. Based on technology developed by Dr. Kazuhiro Furuhashi of the Department of Nephrology at Nagoya University Hospital, Fujifilm Wako has commercialized FM Fix, a tissue fixative that excels in preserving tissue morphology, antigenicity, and with excellent staining properties.
The Role and Challenges of Tissue Fixatives
Tissue fixation is a critical process for protecting biological samples from degradation due to autolysis or decay, ensuring the preservation of proteins and other tissue components. Although formalin fixation is widely used in research and pathology, particularly in preparing microscopic specimens, it can alter the tertiary structure and antigenicity of certain proteins, leading to diminished staining quality. Therefore, selecting the appropriate fixative based on the objectives of the study is crucial.
| Experimental Methods | Immunostaining | Optical Microscopy | Observation of reporters |
| Objectives | Preservation of antigenicity | Preservation of morphology | Preservation of fluorescent proteins |
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Product Overview
FM Fix is a tissue fixative that excels in preserving tissue morphology, antigenicity, and tissue staining properties. While this product is suitable for various tissue fixation purposes, it is particularly effective in preserving fluorescent proteins such as GFP. Furthermore, it is compatible with tissue clearing techniques.
| Preservation of antigenicity | Preservation of morphology | Preservation of fluorescent proteins | Preservation of antigenicity, morphology, and fluorescent proteins |
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Product Lineup
FM Fix (L)
This fixative excels in preserving tissue morphology, tertiary structure, and tissue staining properties. After tissue fixation, the tertiary structure of proteins is well-maintained, enabling consistent detection of antigens such as complement proteins. Additionally, it minimizes the loss of signals from fluorescent proteins like GFP, making it suitable for use in tissue clearing techniques.
FM Fix (s)
FM Fix(s) is a fixative optimized for small tissue samples, such as those obtained from needle biopsies, and for tissues with high permeability, while retaining the fixative properties of FM Fix(L).
Price List
| Product Number | Product Name | Package Size |
|---|---|---|
| 299-97101 | FM Fix (L) | 1 kit |
| 295-97201 | FM Fix (s) | 1 kit |
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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