Trimeric G Protein Gq Family-specific Inhibitor

YM-254890

This compound is a cyclic depsipeptide isolated from the soil bacterium Chromobacterium QS3666 strain.

Among the Gq family of trimeric G proteins, it specifically inhibits signals mediated through Gαq, Gα11, and Gα14 (among about 20 varieties of G protein, those involved in increasing Ca ion concentration) by acting on the GDP/GTP exchange reaction.

This compound is the first membrane-permeable compound that selectively inhibits Gq signals, and will become a useful tool in Gq signal analysis studies.

Features
Basic Information
Structural formula
References
Product List
Related Information

Features

Specifically inhibits signals mediated through Gαq, Gα11, and Gα14
Membrane-permeable, low-molecular-weight compound
Acts in both in vivo and in vitro systems

Basic Information

○ CAS RN^® 568580-02-9

○ Purity：　≥ 95.0 %

○ How to use：　Dissolve in DMSO to a concentration of 1 to 10 mmol/L to make a stock solution. Prior to use, dilute appropriately with the solution of the experimental system.

*Stock solutions should be used as soon as possible.

Structural formula

References

1) Nishimura, A. et al. : Proc. Natl. Acad. Sci. USA, 107(31), 13666 (2010). Structural basis for the specific inhibition of heterotrimeric G_q protein by a small molecule

2) Takasaki, J. et al. : J. Biol. Chem., 279(46), 47438 (2004). A Novel Gα_q/11-selective Inhibitor

3) Taniguchi, M. et al. : Tetrahedron, 59(25), 4533 (2003). Structure of YM-254890, a Novel G_q/11 Inhibitor from Chromobacterium sp. QS3666

4) Taniguchi, M. et al. : J. Antibiotics, 56(4), 358 (2003). YM-254890, a Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp. QS3666.",

Product List

Open All
Close All

For research use or further manufacturing use only. Not for use in diagnostic procedures.

Product content may differ from the actual image due to minor specification changes etc.

If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.

The prices are list prices in Japan.Please contact your local distributor for your retail price in your region.