CYP (Cytochrome P450)
Testosterone, a well known steroid hormone, is used in Cytochrome P450 (CYP) metabolism inhibition and CYP induction drug interaction studies. The metabolism of testosterone to its hydroxy form, 6β-hydroxytestosterone (6β-OH-T) is a commonly used assay to evaluate human CYP3A enzyme activities.
Reaction in vivo
Conversion of testosterone to 6β-hydroxytestosterone reaction is used to determine enzyme activity of CYP3A4.
It is used as a substrate for pharmacokinetics experiments to add to a cell together with a candidate compound that can be a drug and confirm whether it affects drug metabolism.
Column Wakopak® Wakosil®-Ⅱ 5C18HG, 4.6mmφ x 250mm Temp. 40℃ Eluent A: water B: acetonitrile Flow 1.0 mL/min Detector UV 240 nm
Time (min.) A (%) B (%) 1 - 10 50 50 10 - 20 50 → 10 50 → 90 20 - 30 10 90
- Open All
- Close All
CYP for Fluorescent Assay
For research use or further manufacturing use only. Not for use in diagnostic procedures.
Product content may differ from the actual image due to minor specification changes etc.
If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.
The prices are list prices in Japan.Please contact your local distributor for your retail price in your region.