High Boiling Point Cyclic Ether
This product is a solvent of hydrophobic cyclic ether. It is available for various organic synthesis reactions such as reactions with organometallic compounds or as a solvent for polymerization. In addition, the operability after reactions is good with easy to separate from water.
CAS：4717-96-8
C6H12O = 100.16
Boiling point: 105℃
Feature
- Separable for water and MTHP.
- Similar solubitlity as THF.
- Stable for acid and base.
- Stable for oranometallic reagents (e.g. Grignard Reagent, Lithium reagent.)
- Lower volatility (105℃) than THF (65℃) and 2-Mr-THF (80℃).
Physical Properties
| b.p. (℃) |
m.p. (℃) |
Specific gravity (20℃) |
Viscosity (cP) |
Flash point (℃) |
Solubility in water (wt%) |
Moisture | Azeotropic point (℃, water) |
SPvalue* (cal/cm3^0.5) | |
|---|---|---|---|---|---|---|---|---|---|
| MTHP | 105 | <-70 | 0.86 | 0.78 | 6.5 | 1.5 | 1.4 | 84.5 (19.0wt%) | 9.0 |
| THF | 65 | -109 | 0.89 | 0.55 | -15 | ∞ | ∞ | 64 (6.0wt%) | 9.5 |
| 2MTHF | 80 | -136 | 0.85 | 0.60 | -11 | 14 | 4.4 | 88 (15wt%) | 8.9 |
| CPME | 106 | <-140 | 0.86 | 0.55 | -1.0 | 1.1 | 0.3 | 83 (16.3wt%) | 8.4 |
| Et2O | 34.6 | - | 0.70 | 0.71 | -45 | 6.5 | 1.2 | 34.2 (1.3wt%) | 7.6 |
| 1,4-dioxane | 101 | 12 | 1.04 | 1.30 | 11 | ∞ | ∞ | 87.8 (18.4wt%) | 10.0 |
*Calculated according to Hansen solubility parameters a user's handbook 2nd edition, CRC Press, ISBN:0-8493-7248-8
| under acidic conditions | under basic conditions |
|---|---|
| 20% HCl aq./solvent = 1/1(wt%), 50℃ | 20% NaOH aq./solvent = 1/1(wt%), 50℃ |
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 |
Example
Reference
- Onoe, M., Baba, K., Kim, Y., Kita, Y., Tobisu, M. and Chatani, N.: J. Am. Chem. Soc., 134, 19477 (2012).
- Iyanaga, M., Aihara, Y, and Chatani, N.: J. Org. Chem., 79, 11933 (2014).
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