Wako Blog

We introduce a wide range of topics of research, technical reports, tips on experiments and so on.

Front Line of Microglia Research

3rd review: Phagocytic cells in the brain

This article was written by Rena Kono, Yuji Ikegaya, and Ryuta Koyama, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

Phagocytosis is an important process in the immune system. Exogenous viruses and pathogens as well as endogenous cell debris and abnormally aggregated proteins are removed by phagocytes, "professional...

Front Line of Microglia Research

2nd review: Origin of microglia and brain diseases

This article was written by Dr. Kazuyuki Takata, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University.

Microglia are tissue macrophages in the central nervous system (CNS) (i.e., brain and spinal cord) and play a frontline role in CNS immunity. With its unique developmental mode and biology being revea...

Cell Culture Life Science

Novel Tool Box for EVs Therapy in Regenerative Medicine

MSC-derived extracellular vesicles isolated by PS affinity method have high anti-inflammatory and anti-fibrotic effects. Extracellular vesicles (EVs) are small and lipid bilayer particles released by...

Front Line of Microglia Research

1st review: Neuropathic pain

This article was written by Dr. Makoto Tsuda, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University.

In response to harmful stimuli, pain occurs in the body through the nociceptive system to trigger defensive behavior. However, chronic pain called neuropathic pain occurs when the nervous system is da...

Cell Culture Life Science

Co-culture studies to decode 'biological PINs' and exosomes

This article was written by Mr. Takeo Shimasaki of Ginrei Lab Inc.

Recently, it has become evident that extracellular vesicles, including exosomes, play a major role in the communication of various cells in biology. As such, there has been a dramatic increase in the ...

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