Front line of Neurodegenerative Diseases Research

Vol.1 Overview of Alzheimer's Disease

This article was written by Dr. Ryoko Ihara, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital.

Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by neuronal loss with senile plaques and neurofibrillary tangles predominantly in the hippocampus and the temporal ...

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Life Science

Why are exosomes getting a lot of attention?

First described over 30 years ago, exosomes are now being explored with great interest, particularly regarding their involvement in various diseases and in the development of targeted therapies. Exoso...

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Life Science

Proteome analysis of exosomes

This article was written by Koji Ueda Project for Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Japan.

Exosomes are secretory microvesicles derived from intracellular vesicle trafficking pathways, which are involved in extracellular release of unwanted molecules or delivery of molecules to distant cell...

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Life Science

Protein phosphorylation analysis using Phos-tag-based techniques

This article was written by Emiko Kinoshita-Kikuta, Eiji Kinoshita, Tohru Koike Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima, Japan.

Proteins responsible for vital cellular functions use kinase-induced phosphorylation and phosphatase-induced dephosphorylation for their activation and deactivation, respectively. Wide varieties of di...

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