Wako Blog

We introduce a wide range of topics of research, technical reports, tips on experiments and so on.

Front line of Neurodegenerative Diseases Research

Vol. 3. Amyloid β in Alzheimer's Disease

This article was written by Dr. Yukiko Hori and Dr. Taisuke Tomita, Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo

A senile plaque, one of characteristic brain pathological features of Alzheimer's disease (AD), is the brain parenchymal accumulation of abnormally aggregating insoluble proteins forming amyloid fibri...

Front line of Neurodegenerative Diseases Research

Vol. 2. Tau protein in Alzheimer's disease

This article was written by Dr. Masato Hasegawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science.

Alzheimer's disease (AD) is neuropathologically characterized by two abnormal structures: senile plaques and neurofibrillary tangles. Senile plaques are extracellular structures composed of amyloid β ...

Front line of Neurodegenerative Diseases Research

Vol. 1. Overview of Alzheimer's Disease

This article was written by Dr. Ryoko Ihara, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital.

Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by neuronal loss with senile plaques and neurofibrillary tangles predominantly in the hippocampus and the temporal ...

Life Science

Why are exosomes getting a lot of attention?

First described over 30 years ago, exosomes are now being explored with great interest, particularly regarding their involvement in various diseases and in the development of targeted therapies. Exoso...

Life Science

Proteome analysis of exosomes

This article was written by Koji Ueda Project for Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Japan.

Exosomes are secretory microvesicles derived from intracellular vesicle trafficking pathways, which are involved in extracellular release of unwanted molecules or delivery of molecules to distant cell...

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