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We introduce a wide range of topics of research, technical reports, tips on experiments and so on.

Sep, 2019

Front Line of Neurodegenerative Diseases Research

Vol. 5. Overview of Parkinson's Disease

This article was written by Dr. Hodaka Yamakado, Department of Neurology, Graduate School of Medicine, Kyoto University

Parkinson's disease (PD) is a neurodegenerative disease clinically characterized by Parkinson symptoms and pathologically characterized by Lewy bodies and dopaminergic neuronal death.

Sep, 2019

Front Line of Neurodegenerative Diseases Research

Vol. 4. Molecular Imaging in Alzheimer's Disease

This article was written by Dr. Makoto Higuchi, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology.

Alzheimer's disease (AD) is neuropathologically characterized by the deposition of protein aggregates and progressive neuronal death in the brain. Pathological protein fibrils deposited in the brain o...

Sep, 2019

Front Line of Neurodegenerative Diseases Research

Vol. 3. Amyloid β in Alzheimer's Disease

This article was written by Dr. Yukiko Hori and Dr. Taisuke Tomita, Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo

A senile plaque, one of characteristic brain pathological features of Alzheimer's disease (AD), is the brain parenchymal accumulation of abnormally aggregating insoluble proteins forming amyloid fibri...

Sep, 2019

Front Line of Neurodegenerative Diseases Research

Vol. 2. Tau protein in Alzheimer's disease

This article was written by Dr. Masato Hasegawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science.

Alzheimer's disease (AD) is neuropathologically characterized by two abnormal structures: senile plaques and neurofibrillary tangles. Senile plaques are extracellular structures composed of amyloid β ...

Sep, 2019

Front Line of Neurodegenerative Diseases Research

Vol. 1. Overview of Alzheimer's Disease

This article was written by Dr. Ryoko Ihara, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital.

Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by neuronal loss with senile plaques and neurofibrillary tangles predominantly in the hippocampus and the temporal ...

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Vol. 5. Overview of Parkinson's Disease

This article was written by Dr. Hodaka Yamakado, Department of Neurology, Graduate School of Medicine, Kyoto University

Vol. 4. Molecular Imaging in Alzheimer's Disease

This article was written by Dr. Makoto Higuchi, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology.

Vol. 3. Amyloid β in Alzheimer's Disease

This article was written by Dr. Yukiko Hori and Dr. Taisuke Tomita, Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Vol. 2. Tau protein in Alzheimer's disease

This article was written by Dr. Masato Hasegawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science.

Vol. 1. Overview of Alzheimer's Disease

This article was written by Dr. Ryoko Ihara, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital.

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