Genes required for autophagy in mammalian cells include Atg5, Atg7, LC3, and Beclin. Atg5, Atg7, and LC3, which may be important in the elongation of the isolation membrane, and Becilin, which may be important in the early stage of autophagosome formation, are widely conserved from yeast to mammalian cells. However, autophagy that does not require Atg5, Atg7, or LC3 has been reported, suggesting that other mechanisms may exist.
FUJIFILM Wako handles the antibodies against Atg7, LC3, and SQSTM1/A170/p62, which is expressed in an oxidative stress-dependent manner and binds to LC3.


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