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To prevent human ES/ iPS cell death

Y-27632, MF

Y-27632, MF was registered in the Drug Master File (MF) in Japan as additives for culture medium in September 2015. We ensure high stability and quality of the products by validating the manufacturing and analytical processes and implementing change control strategies.

GMP products comming soon!

FUJIFILM Wako will provide the small molecules produced through GMP based on ICHQ7 in 2021.

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What is Y-27632?

Selective and potent ROCK inhibitor

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Y-27632 plays various roles including contraction of vascular smooth muscle cells via ROCK signaling pathways. Furthermore, it suppresses the cell death of ES/iPS cells at cell dispersion, and that it improves cell survival after cryopreservation.

CAS RN®. 331752-47-7
C14H21N3O・2HCl・H2O=338.27

Product Specification

Requirement Specification
Appearance White to pale yellow, crystalline powder to powder
Assay (HPLC) ≧98.0%
Solubility in water To pass test
Specific rotation [α]D20(c=1.0,CH3OH) +2.0~+10.0゜
Bacterial endotoxins※ <0.25EU/mg
Viable count test※ 20CFU/g以下
Mycoplasma test※ To pass test

  • Tests for mycoplasma, endotoxin, and viable bacteria are performed for every lot as part of standard tests; however, the results are not required for MF registration.
  • Registration in the Drug Master File (MF) does not indicate that the product was tested for its quality and safety by the Ministry of Health, Labor and Welfare (Pharmaceuticals and Medical Devices Agency).

References

Uehata, M., et al. : Nature, 389, 990 (1997).
Sakamoto, K., et al. : J. Pharmacol. Sci., 92, 56 (2003).
Nishimaru, K., et al. : J. Pharmacol. Sci., 92, 424 (2003).
Watanabe, K., et al. : Nat. Biotechnol., 25, 681 (2007).
Martin-Ibanez, R., et al. : Hum. Reprod., 23, 2744 (2008).
Claassen, DA., et al. : Mol. Reprod. Dev., 76, 722 (2009).
Kawamata, M., et al. : Proc. Natl. Acad. Sci. USA., 107, 14223 (2010).
Ito, H., et al. : Liver Int., 32, 592 (2012).
Katsuda,T., et al. : Cell Stem Cell, 20, 41 (2017).
Okae, H., et al. : Cell Stem Cell, 22, 50 (2018).
Ogawa, K., et al. : Sci. Rep., 8, 3615 (2018).
Ayabe, H., et al. : Stem Cell Reports., 11, 306 (2018).

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MF-registered (Small Molecular compounds)

Regenerative medicine product material qualification consulted product

Product content may differ from the actual image due to minor specification changes etc.

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