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Piceatannol

for Cellbiology
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep at 2-10 degrees C.
CAS RN® :
10083-24-6
Molecular Formula :
C14H12O4
Molecular Weight :
244.24
  • Structural Formula
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Distributor
169-21661
Barcode No
4987481442115
10mg
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Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate

Overview / Applications

Outline An activator of human deacetylase class III (SIRT1).An inhibitor of non-reception type tyrosine kinase Syk.
This product is for research use only. Do not administer it to human.

Cell Biological ResearchFor Research on Cell Cycle and TranscriptionHistone deacetylase (HDAC) plays a central role in chromatin structure formation associated with the nuclear distribution of DNA. There are presently 17 known types of this enzyme in mammals, which are classified into 3 classes (see below). Also, HDAC Class III has been reported to be associated with regulation of aging and life span.

  • Mammalian HDAC Class I: Localized in the nucleus. Is similar to RPD3 enzyme. [Types: HDAC1-3, 8]
  • Mammalian HDAC Class II: Localized in the nucleus and cytoplasm and shuttles between the two. Similar to HDAC1 enzyme. [Types: HDAC4-7, 9, 10]
  • Mammalian HDAC Class III: NAD-dependent enzyme. Localized in the nucleus and cytoplasm. Also called Sirtuin and is similar to SIR2 enzyme. [Types: Sirt 1-7]

[Related Products]
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    Activator of HDAC Class III and inhibitor of kinase Syk.

  • Sirtinol (Wako Cat.#197-13671 (5 mg)) Inhibitor of HDAC Class III. Cell-permeable.

  • Trichostatin A (Wako Cat.#203-17561 (1 mg); #209-17563 (5 mg)) Potent and reversible inhibitor of HDAC Class I and II.

  • Valproic Acid (Wako Cat.#227-01071 (5 g); #225-01072 (25 g)) Inhibitor of HDAC1.

[Reference]
1) Howitz, K. T., et al.: Nature, 425, 191 (2003).
Shown on the page #4 of Wako Product Update No. 13.

Property

Appearance White - brown, crystals - powder

Manufacturer Information

Alias

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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