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FK506 Monohydrate

for Pharmacology Research
Specification Assay :
98.0+% (HPLC)
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep below 25 degrees C.
CAS RN® :
109581-93-3
Molecular Formula :
C44H69NO12・H2O
Molecular Weight :
822.03
  • Structural Formula
  • Label
  • Packing
Comparison
Product Number
Package Size
Price
Inventory
Distributor
063-06191
Barcode No
4548995018939
5mg
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In stock in Japan

Distributor
069-06193
Barcode No
4548995018946
25mg
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In stock in Japan

Document

Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate

Application

Overview / Applications

Outline This product is for research use only. Do not administer it to human.


FK506 is a potent immunosuppressant, neuroprotective agent and nerve regenerator. In vitro, FK506 has been shown to block T cell proliferation. Although it normally forms a complex with FK506 binding protein 12 (FKBP12), the molecule can also bind with calcineurin to downregulate the expression of various cytokines such as IL-2 and interferon, which subsequently leads to decreased extracellular T cell differentiation/proliferation.

Property

Appearance White - nearly white, crystalline powder - powder

Manufacturer Information

Alias

  • Tacrolimus Monohydrate
    (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Monohydrate

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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