BES-H2O2-Ac

for Cellbiology

Specification Assay :: 90.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at RT.

CAS RN^® :: 728912-55-8
Molecular Formula :: C28H11F7O8S
Molecular Weight :: 640.44

Structural Formula
Label
Packing

Comparison	Product Number	Package Size	Price	Inventory
	Distributor 028-17811 Barcode No 4548995009746	1mg	Inquire	In stock	Certificate of Analysis

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Overview / Applications
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Product Specification Sheet

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Overview / Applications

Outline	This product is for research use only. Do not administer it to human. When deacetylated within the cell by esterase, this deacetylated product (see the reaction below) reacts with hydrogen peroxide by fluorescing. As such, it is ideal as a fluorescent indicator of intracellular hydrogen peroxide. This product reacts with hydrogen peroxide more specifically compared to other fluorescent indicators on the market. [Advantages] Selectively reacts with hydrogen peroxide Membrane permeability Enables monitoring of intracellular hydrogen peroxide This product is for research use only. Do not administer it to human. *Highly Selective Fluorescent Probe for Hydrogen Peroxide* [Features] Highly selectivity toward H₂O₂ Permeable to cell membrane Detectability of cell-derived H₂O₂ Applicable to Molecular Imaging Reactive oxygen species (ROS) such as superoxide (O₂^-.),hydrogen peroxide (H₂O₂), and the hydroxyl radical (HO^.) are important mediators of pathological processes in various diseases. 2',7'-Dichlorofluorescein (DCFH) and its diacetyl derivative have been widely used as fluorescent probes for measuring cell-derived H₂O₂, but these compounds suffer from the major drawback that they are poorly selective toward H₂O₂.BES-H₂O₂ is a probe for cell-derived H₂O₂ with high selectively. It is applicable to clarifying cell response as well as dynamic function of H₂O₂ with diseases. Solubility: Soluble in DMSO, DMF and acetonitrileFluorescence: excitation wavelength: 485 ± 20 nm emission wavelength: 515 ± 20 nm [References] Maeda, H., Fukuyasu, Y., Yoshida, S., Fukuda, M. Saeki, K.. Matsuno, H., Yamauchi, Y., Yoshida, K., Hirata, K. and Miyamoto, K. : Angew. Chem. Int. Ed., 43, 2389 (2004). Maeda, H., Matsuura, S., Nishida, M., Senba, T., Yamauchi, Y. and Ohmori, H.: Chem. Pharm. Bull., 49, 294 (2001). [Related Products] Thiol/Selenol Selective Fluorescent Probe BES-Thio (Wako Cat. #025-15481 (1 mg)) [Fluorescence] excitation wavelength: 495 nm; emission wavelength: 535 nm Superoxide Selective Fluorescent Probes BES-So (cell-impermeant) (Wako Cat. #028-16211 (1 mg)) BES-So-AM (Cell-impermeant) (Wako Cat. #021-17801 (1 mg)) [Fluorescence] excitation wavelength: 505 nm; emission wavelength: 544 nm Highly Selective Fluorescent Probes for Hydrogen Peroxide BES H₂O₂ (cell-impermeant)(Wako Cat. #021-16201 (1 mg)) BES H₂O₂-Ac (cell-permeant)(Wako Cat. #028-17811 (1 mg)) [Fluorescence] excitation wavelength: 485 nm; emission wavelength: 515 nm
Purpose	Detection of hydrogen peroxide in cells.

Outline

This product is for research use only. Do not administer it to human.

When deacetylated within the cell by esterase, this deacetylated product (see the reaction below) reacts with hydrogen peroxide by fluorescing. As such, it is ideal as a fluorescent indicator of intracellular hydrogen peroxide. This product reacts with hydrogen peroxide more specifically compared to other fluorescent indicators on the market.

[Advantages]

Selectively reacts with hydrogen peroxide
Membrane permeability
Enables monitoring of intracellular hydrogen peroxide

This product is for research use only. Do not administer it to human.

Highly Selective Fluorescent Probe for Hydrogen Peroxide

[Features]

Highly selectivity toward H₂O₂
Permeable to cell membrane
Detectability of cell-derived H₂O₂
Applicable to Molecular Imaging

Reactive oxygen species (ROS) such as superoxide (O₂^-.),hydrogen peroxide (H₂O₂), and the hydroxyl radical (HO^.) are important mediators of pathological processes in various diseases. 2',7'-Dichlorofluorescein (DCFH) and its diacetyl derivative have been widely used as fluorescent probes for measuring cell-derived H₂O₂, but these compounds suffer from the major drawback that they are poorly selective toward H₂O₂.BES-H₂O₂ is a probe for cell-derived H₂O₂ with high selectively. It is applicable to clarifying cell response as well as dynamic function of H₂O₂ with diseases.

Solubility: Soluble in DMSO, DMF and acetonitrileFluorescence:

excitation wavelength: 485 ± 20 nm
emission wavelength: 515 ± 20 nm

[References]

Maeda, H., Fukuyasu, Y., Yoshida, S., Fukuda, M. Saeki, K.. Matsuno, H., Yamauchi, Y., Yoshida, K., Hirata, K. and Miyamoto, K. : Angew. Chem. Int. Ed., 43, 2389 (2004).
Maeda, H., Matsuura, S., Nishida, M., Senba, T., Yamauchi, Y. and Ohmori, H.: Chem. Pharm. Bull., 49, 294 (2001).

[Related Products]

Thiol/Selenol Selective Fluorescent Probe

[Fluorescence] excitation wavelength: 495 nm; emission wavelength: 535 nm

Superoxide Selective Fluorescent Probes

[Fluorescence] excitation wavelength: 505 nm; emission wavelength: 544 nm

Highly Selective Fluorescent Probes for Hydrogen Peroxide

₂

[Fluorescence] excitation wavelength: 485 nm; emission wavelength: 515 nm

Purpose

Detection of hydrogen peroxide in cells.

Property

Appearance	White - slightly brown, crystalline powder - powder

Same CAS list

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Product List

Product Name
BES-H2O2 (Cell-impermeant)	for Cellbiology

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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