BES-So-AM(Cell-permeant)

Highly Selective Fluorescent Probes
Superoxide selective fluorescent probe
Since superoxide (O₂^-.) is an active oxygen having weak cytotoxicity, it is getting attention as a molecule positioned on the uppermost stream side of various active oxygen species.O₂^-. is detected based on different chemiluminescence and fluorescence methods.
Among these detection methods, hydroethidine is commonly used but existing probes including hydroethidine are pointed out to have low selectivity for O₂^-..
BES-So shows a fluorescence by non-redox- reaction dependent mechanism, and indicates high selectivity for O₂^-..

[Features]
After cellular uptake, deacetoxymethyl compound by the action of cellular esterase responds to O₂^-.
[References]
Maeda, H., Yamamoto, K., Nomura, Y., Kohno, I., Hafsi, L., Ueda, N., Yoshida, S., Fukuda, M., Fukuyasu, Y., Yamauchi, Y. and Itoh, N.: J. Am. Chem. Soc., 127, 68 (2005).

[Related Products]

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[Fluorescence] excitation wavelength: 495 nm; emission wavelength: 535 nm

• Superoxide Selective Fluorescent Probes

BES-So (cell-impermeant) (Wako Cat. #028-16211 (1 mg))
BES-So-AM (Cell-impermeant) (Wako Cat. #021-17801 (1 mg))
[Fluorescence] excitation wavelength: 505 nm; emission wavelength: 544 nm

• Highly Selective Fluorescent Probes for Hydrogen Peroxide

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