Anti Human EGFR, Monoclonal Antibody (EMab-134)
- for Immunochemistry
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
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100ug
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In stock in Japan |
Document
Product Overview
Epidermal growth factor receptor (EGFR) binds to EGF and belongs to the ErbB family of receptor tyrosine kinases. EGFR is crucial for cell proliferation, and mutations or overexpression of EGFR have been observed in various types of human cancers. Notably, EGFR overexpression is associated with the progression, metastasis, and poor prognosis of cancers, including head and neck cancer, lung cancer, and colorectal cancer1).
Anti Human EGFR, Monoclonal Antibody (EMab-134) is a mouse monoclonal antibody against human EGFR2). It is suitable for use in immunohistochemistry, flow cytometry, and Western blotting.
Antibody Information
| Clonality | Monoclonal |
|---|---|
| Antigen | Human EGFR, recombinant [extracellular domain] expressed in LN229 Cell Line |
| Host | Mouse |
| Formulation | PBS, 0.1% sodium azide |
| Concentration | 1.0 mg/mL |
| Subclass | IgG1・κ |
| Conjugate | Unconjugated |
| Cross-reactivity | Human |
| Application | Flow cytometry: 1-10 μg/mL IHC: 5 μg/mL WB: 1 μg/mL |
Application Data
Immunohistochemistry
Sample: Mouth cancer tissue
Antibody concentration: 5 μg/mL
Western Blotting
Antibody concentration: 1 μg/mL
2nd antibody, detection: Envision+ (Agilent Technologies, Inc.)
References
- Mendelsohn, J.: Endocrine-Related Cancer, 8(1), 3(2001).
The epidermal growth factor receptor as a target for cancer therapy - Itai, S. et al.: Monoclon. Antib. Immunodiagn. Immunother., 36(6), 272(2017).
Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity
Property
| Concentration | Protein : 1.0mg/mL |
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Alias
- ErbB1
ERRP
HER1
epidermal growth factor receptor
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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