TaDiAS-[(4R,5R)-2,2-dipropyl-N,N,N',N'-tetrakis(4-methylbenzyl)] Bis(tetrafluoroborate)

[Green Chemistry]TaDiAS

TaDiAS (Tartrate-derived DiAmmonium Salt), an asymmetric phase-transfer catalyst which contains 2 quarternary ammonium salts in its molecule, was developed by the Shibasaki group of The University of Tokyo.(It is considered that) TaDiAS is believed to produce high asymmetric yields of asymmetric compounds by fixation of the anion position in asymmetric space as a result of the collaboration of 2 quarternary ammonium salts.TaDiAS, the iodide salt, show high catalytic activity and high enantioselectivity in asymmetric alkylation of alpha-amino acid derivatives. TaDiAS, the tetrafluoroboric acid, show high catalytic activity and high enantioselectivity in asymmetric Michael addition of alpha-amino acid derivatives^{1) 2)}

[References]

1. T. Shibuguchi, Y. Fukuta, Y. Akachi, A. Sekine, T. Ohshima, M. Shibasaki : Tetrahedron Lett., 43, 9539 (2002).
2. T. Ohshima, V. Gnanadesikan, T. Shibuguchi, Y. Fukuta, T. Nemoto, M. Shibasaki : J. Am. Chem. Soc., 125, 11206 (2003).