Rh-Pt/ (DMPSi-Al2O3)

This product is an immobilized catalyst in which rhodium (Rh) and platinum (Pt) are supported on dimethylpolysilane (DMPSi) and alumina (Al₂O₃). The rhodium and platinum nanoparticles show high activity and act as a strong hydrogenation catalyst for the aromatic ring. Normally, hydrogenation of aromatic rings requires high pressure conditions, but when this catalyst is used in a flow reaction, it proceeds under mild conditions (50 to 80 ° C, 1 atm H₂). Depending on the substrate, the reaction proceeds at atmospheric pressure even in batch reactions.

• Hydrogenation of aromatic rings under mild conditions (50-80°C, 1 atm)
• Maintains catalytic activity in continuous operation for 50 days or more with the continuous-flow method
• The continuous-flow method has maximum 27 times TOF (turnover frequency) than the batch method.

Hydrogenation of aromatic rings in the continuous-flow system

The durability of catalyst

The reaction conversion ratio is maintained quantitatively throughout a run of 1214 h (>50 days).

Hydrogenation of aromatic rings in the batch system

Recovery and reuse of catalyst in batch system

Selective partial hydrogenation of aromatic rings

One-pot synthesis of donepezil

Reductive Cross-Amination

References

1. Hydrogenation of aromatic rings
   “Polysilane-Immobilized Rh-Pt Bimetallic Nanoparticles as Powerful Arene Hydrogenation Catalysts: Synthesis, Reactions under Batch and Flow Conditions, and Reaction Mechanism”
   Miyamura, H., Suzuki, A., Yasukawa, T., and Kobayashi, S. : J. Am. Chem. Soc., 140, 11325 (2018). DOI：10.1021/jacs.8b06015
2. Reductive Cross-Amination　OPEN ACCESS
   ”Highly Selective Reductive Cross-Amination between Aniline or Nitroarene Derivatives and Alkylamines Catalyzed by Polysilane-Immobilized Rh/Pt Bimetallic Nanoparticles”
   Suzuki, A., Miyamura, H., and Kobayashi, S. : Synlett , 30, 387 (2019). DOI : 10.1055/s-0037-1611341