Lovastatin

for Biochemistry

Specification Assay :: 95.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at 2-10 degrees C.

CAS RN^® :: 75330-75-5
Molecular Formula :: C24H36O5
Molecular Weight :: 404.54

Citations (1)

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 125-04581 Barcode No 4987481371590	25mg	List Price JPY 30,000	Inquire	Certificate of Analysis

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25mg

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Overview / Applications

Outline	This product is for research use only. Do not administer it to human. Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are the rate limiting enzymes in cholesterol biosynthesis. By blocking the conversion of HMG-CoA to the cholesterol precursor mevalonate, these agents inhibit hepatic synthesis of cholesterol, causing a subsequent stimulation of LDL receptors and an increase in the clearance of LDL and its precursor particles from the circulation. (1) Singer, I. I., et al., Proc. Natl. Acad. Sci. USA, 85, 5264 (1988) (2) Endo, A., et al., FEBS LETTERS, 72, 323 (1976) Lovastatin is an anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase. Note: Not available for sale in the US. Compactin [ML-236B], 95+% (Cat.#033-17301 (25 mg)) Simvastatin, 95+% (HPLC) (Cat.#193-12051 (25 mg), 199-12053 (100 mg)) Pravastatin Sodium, 95+% (HPLC)(Cat.#162-19821 (25 mg), 169-19823 (100 mg))

Outline

This product is for research use only. Do not administer it to human.
Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are the rate limiting enzymes in cholesterol biosynthesis. By blocking the conversion of HMG-CoA to the cholesterol precursor mevalonate, these agents inhibit hepatic synthesis of cholesterol, causing a subsequent stimulation of LDL receptors and an increase in the clearance of LDL and its precursor particles from the circulation.

(1) Singer, I. I., et al., Proc. Natl. Acad. Sci. USA, 85, 5264 (1988)
(2) Endo, A., et al., FEBS LETTERS, 72, 323 (1976)
Lovastatin is an anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase.
Note: Not available for sale in the US.

Compactin [ML-236B], 95+% (Cat.#033-17301 (25 mg))
Simvastatin, 95+% (HPLC) (Cat.#193-12051 (25 mg), 199-12053 (100 mg))
Pravastatin Sodium, 95+% (HPLC)(Cat.#162-19821 (25 mg), 169-19823 (100 mg))

Property

Appearance	White - nearly white, crystals - powder
Melting Point	174.5 degrees C

Manufacturer Information

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Same CAS list

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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